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By Vidya Bhushan Gupta

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We will also present what is currently known about autism risk factors and discuss challenges to conducting epidemiological studies of autism. In this chapter, we will use the term ASD to refer to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (5) diagnosis of autistic disorder, Asperger disorder, and pervasive developmental disorder –not otherwise specified (PDD-NOS). Where possible, we will indicate those studies that attempted to differentiate between autistic disorder and the broader spectrum of ASDs.

A The prevalence rate that is provided represents an average prevalence rate. b The prevalence study provided overall rate only. c 64% had MR-based IQ data and 68% had cognitive impairment based on IQ and developmental tests. Copyright © 2004 Marcel Dekker, Inc. 0/— NR Case enumeration 34 64,68c Epidemiology of Autism 25 Although Kanner recorded brilliant descriptions of the clinical features of autism, it was not until 1956 that he and Eisenberg published the Kanner diagnostic criteria for early infantile autism, which included (16): 1.

Juul-Dam N, Townsend J, Courchesne E. Prenatal, perinatal, and neonatal factors in autism, pervasive developmental disorder-not otherwise specified, and the general population. Pediatrics 2001; 107(4):E63. Madsen KM, Hvid A, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002; 347(19):1477– 1482. Fombonne E, Chakrabarti. No evidence for a new variant of measles-mumpsrubella-induced autism. org/ cgi/content/full/108/4/e58 Gillberg C, Heijbel H.

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