By Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.), Nanette F. Santoro, Genevieve Neal-Perry (eds.)
Amenorrhea: A Case-Based medical consultant is a accomplished assessment of the present wisdom concerning general lady reproductive body structure. Replete with attention-grabbing case vignettes and delivering diagnostic algorithms and healing thoughts for amenorrhea, Amenorrhea: A Case-Based scientific advisor is split into 3 sections. the 1st part consists of 2 chapters that offer a radical overview of easy technology and scientific wisdom in regards to the organ platforms chargeable for basic body structure of the menstrual cycle. the second one part contains dialogue approximately menstrual cycle disruption because it pertains to hypothalamic-pituitary disorder, surgical and common menopause, genetic defects, untimely ovarian failure/insufficiency and the consequences of caloric extra and limit. The 3rd part deals an replace at the physiological results of lengthy amenorrhea brought on surgically or by way of hypothalamic disorder and likewise comprises an unique bankruptcy that focuses exclusively at the impression of race and ethnicity at the incidence and prognosis of amenorrhea. Amenorrhea: A Case-Based scientific advisor brings jointly chapters from well known specialists who supply cutting-edge, clinically worthwhile details in a case-based, reader-friendly model. This identify may be a welcome boost to the bookshelves of all clinicians who perform in women’s wellbeing and fitness settings.
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Additional info for Amenorrhea: A Case-Based, Clinical Guide
Mol Cell Endocrinol 282:130–142 71. Parrott JA, Skinner MK (1998) Thecal cell-granulosa cell interactions involve a positive feedback loop among keratinocyte growth factor, hepatocyte growth factor, and Kit ligand during ovarian follicular development. Endocrinology 139:2240–2245 72. McConnell NA, Yunus RS, Gross SA, Bost KL, Clemens MG, Hughes FM Jr (2002) Water permeability of an ovarian antral follicle is predominantly transcellular and mediated by aquaporins. Endocrinology 143:2905–2912 73.
MMPs are generally secreted in an inactive form. Pro-MMPs are made in increasing numbers prior to menstruation in response to local signals as well as progesterone withdrawal. A tightly regulated balance among MMP production, activation, and inhibition controls the activity of MMPs and hence tissue integrity. MMPs are also regulated by tissue inhibitors of MMPs (TIMPs). Withdrawal of progesterone at menstruation leads to increased MMP production and activation as well as release of TIMPs, thus causing matrix degradation.
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