Download Adhesion in Leukocyte Homing and Differentiation by F. Melchers (auth.), Dominique Dunon Ph.D., Charles R. PDF

By F. Melchers (auth.), Dominique Dunon Ph.D., Charles R. Mackay Ph.D., Beat A. Imhof Ph.D. (eds.)

This quantity of present subject matters in Microbiology and Immunology used to be deliberate in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held on the Basel Institute for Immunology in November 1992, and plenty of of the workshop audio system have contributed to it. phone adhesion is among the such a lot dynamic fields of organic examine and awarded during this booklet is the present wisdom at the constitution and serve as of the foremost households of mobile adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. complicated interactions among the participants of those households mediate diversified adhesion services, together with leukocyte-leukocyte interactions, lymphocyte homing, irritation, and lymphocyte-stromal telephone interplay in the course of hematopoiesis. loads of emphasis is put on the regulatory components that regulate the expression and serve as of adhesion molecules. Cytokines not just result in the expression of convinced adhesion molecules, yet can also adjust their practical prestige. for example, the integrins exist in both an inactive nonfunctional shape or an energetic practical shape, and a few intracellular or extracellular stimuli alter integrin functionality. this is often really very important in the course of leukocyte binding to endothelium and transendothelial migration, which proceeds via a cascade of adhesion occasions. even though phone adhesion molecules play a massive function in lots of strategies, this publication concentrates on their position in the immune method. a few chapters talk about the migration of lymphocytes among hematopoietic organs corresponding to the thymus, lymph nodes, Peyer's patches, and spleen.

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Additional resources for Adhesion in Leukocyte Homing and Differentiation

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1992). The ligand interactions involved in PECAM -1 -mediated adhesion are complex. PECAM-1 appears to be able to interact both with itself (homophilic interaction) (ALBELDA et al. 1991) and/or with other non- PECAM-1 mole- Platelet Endothelial Cell Adhesion Molecule (CD31) 41 cules (heterophilic interaction) (MULLER et al. 1992), a feature that has been increasingly recognized among other cell adhesion proteins of the Ig superfamily, including Ng-CAM (GRUMET and EDELMAN 1988), Nr-CAM (MAURO et al.

There is also no evidence as yet that integrin function can be modulated by alternative splicing of mRNA for the cytoplasmic domain of integrin subunits. However, the loss of function seen with some deletion mutants of the cytoplasmic domains of integrin subunits suggests that such a mechanism may well exist. In a different way the binding capacity of a given cell can be influenced by regulating the expression of its ligand or by alternative mRNA splicing of sequences encoding the cell binding domain in their ligands.

Damsky CH (1990) The oc, / f3, and OC6/ f3, integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Bioi 110: 2175-2184 Hautanen A. Gailit J, Mann DM, Ruoslahti E (1989) Effects of modifications of the RGD 28 A. Sonnenberg sequence and its context on recognition by the fibronectin receptor. J Bioi Chem 264: 1437-1442 Hayashi y, Haimovich B, Reszka A. Boettiger D, Horwitz A (1990) Expression and function of chicken integrin f3, subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

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